Fig. 2

Examples of phylogenetic trees of different tumor subtypes, based on mutational signatures. The mutational signatures were generated separately for variants shared between PT and M or private to each sample. The relative contribution of the signature were then annotated to the phylogenetic tree of 12 breast cancers cases of all 4 subtypes (luminal A, luminal B, Her2, and TNBC). HR, homologous recombination; MMR, mismatch-repair deficiency